Activation and destruction are linked


Transcriptional activation domains usually overlap with degrons. The domain structure of 28 transcription factors is shown; DNA-binding domains are gray, TADs are blue, degrons are orange, and red represents the overlap of TADs and degrons. Although the overlap between these elements is not always perfect, it is worth remembering that different studies have typically defined each type of element, and that different sets of mutations (which define the boundaries) have been used in these studies. Why would an element capable of activating transcription also signal ubiquitin-dependent proteolysis?

© Bill Tansey 2019