The MYC family of oncoproteins

Cartoon of MYC proteins. At the top is a representation of generic MYC, showing the transcriptional activation and DNA-binding domains, as well as the central portion that we study. Below is a representation of the three MYC family members, C-, N-, and L-MYC. Highlighted in each are regions of stringent sequence conservation: Five MYC boxes (MbI, MbII, MbIIIa, MbIIIb, and MbIV) and the basic-region-helix-loop-helix-leucine-zipper (BR-HLH-LZ) that dimerizes with MAX to form the DNA-binding domain.

© Bill Tansey 2017