Facilitated recruitment of MYC to chromatin via WDR5

Facilitated recruitment of MYC to chromatin by interaction with WDR5. We propose that target gene recognition by MYC–MAX dimers is driven by two critical sets of interactions: one between MYC/MAX and DNA, and another between MYC and a proximal and chromatin-bound molecule of WDR5. The avidity provided by this mechanism can stabilize MYC on chromatin and determine the precise set of target genes that respond to MYC. We wish to identify proteins that work with WDR5 to facilitate MYC recruitment (orange shapes) and learn the full extent to which this process contributes to tumorigenesis.

© Bill Tansey 2021