The proteasome—a swiss army knife for transcription?

The Swiss Army Knife model of proteasome function in transcription. This model posits that the entire 26S proteasome is recruited into transcriptional processes, and its various activities are used depending on the molecular requirements. (TOP) The proteasome uses a combination of proteolytic and non-proteolytic functions to control activator binding, residency time, and co-activator exchange on promoter DNAs. (MIDDLE) We posit that proteasomes enter the open reading frame (ORF) of transcribed genes, where their ATPase activities stimulate elongation, while their proteolytic functions serve to remove terminally stalled pol II complexes that may arise. (BOTTOM) Proteolytic activity of the proteasome is also important for attenuating cryptic, non-authentic, transcription complexes, and for processes required for appropriate termination of the transcription event. We wish to understand how proteasomes are recruited to chromatin and what they do once they get there.

© Bill Tansey 2019